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Preimplantation genetic diagnostics

PGD or preimplantation genetic diagnostics is used along with IVF or IVF with ICSI and is basically a method of embryo genetic anomalies diagnosing before its transfer into the body of a woman. This diagnostics allows to eliminate genetic diseases transmission to a future child and to foreseen miscarriage.

Preimplantation genetic diagnostics can be recommended not only to infertile couples. It can be offered to women with miscarriage anamnesis or one of the partners has some genetic deviations. In the result of PGD only healthy embryos are selected for further transfer to the uterus of a mother.

Indications to PGD:

  • Women above 35 years old
  • miscarriage anamnesis
  • prior IVF treatment with no desirable result
  • couples, in which one has some genetic deviations

On the third day after fertilization, 1-2 blastomeres are derived from each 6-8-cell embryo using special micromanipulators. These cells contain chromosomes, analysis of which allows to diagnose or exclude pathologies. PGD cannot harm embryos, as after the retrieval of the cells it develops further the same way. For implementation of the preimplantation genetic diagnostics of embryo, usually the techniques of FISH (Fluorescent in situ hybridization), PCR (polymerase chain reaction) and CGH (comparative genome hybridization) and NGS ( next generation sequencing) are used. Choice of the PGD method is made by a doctor geneticist individually for each case.

Why is PGD important?

According to experience of many doctors, this diagnosing method is the only possible and exact to detect embryo chromosomal deviations. Thanks to this method it is possible to prevent birth of a child with genetic conditions, as well as to increase the efficiency of IVF and decrease the risk of miscarriage. Besides, using PGD after in vitro fertilization the sex of a future baby can be defined before its transfer.

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